Mycobacterium tuberculosis (M.tb) facts
- M.tb is the leading infectious cause of death worldwide.
- Globally, someone dies of tuberculosis (TB) every 17 seconds.
- There is currently no vaccine which will stop the epidemic.
Pictured from left to right: Debbie Cross, Patzy Villagrana, Megan Maerz, Elizabeth Ramirez, Megan Files, Stephen Makatsa, Nathan Kieswetter, Jolie Phan, Chetan Seshadri, Cassie Winter, Erik Layton, Krystle Yu, Emma Bishop, Tori Tappen, Angela Zhou
- Advance knowledge of immune factors required for protection against M. tuberculosis in humans
- Elucidate the functions and phenotypes of M.tb-specific T cell populations (classical and non-classical) using immunologic and computational approaches in collaborative human cohort studies
- Collaborate on other immune cell subsets or animal models if such studies extend the results of human studies
Our Recent Publications
- T-SPOT.TB reactivity in Southern African children with and without in utero HIV exposure.
- Cytotoxic T Cells Targeting Spike Glycoprotein Are Associated with Hybrid Immunity to SARS-CoV-2.
- Vaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells.